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KMID : 0869619960130010064
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Journal of Korean Society of Hospital Pharmacists
1996 Volume.13 No. 1 p.64 ~ p.69
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The relationship of glucose and insulin for the optimal glucose control in diabetes receiving Total Parenteral Nutrition
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이주연/Lee, J.Y.
이영필/김호순/박경호/조남춘/신완균/Lee, Y.P./Kim, H.S./Park, K.H./Cho, N.C./Shin, Y.K.
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Abstract
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Hyperglycemia is main problems in diabetes or pancreatic disease patients on Total Parenteral Nutrition (TPN) therapy. The Insulin therapy is the first artifact in hyperglycemia by admixturing insulin to TPN solution.
So, the purpose of our study is to calculate the insulin requirement for optimal blood glucose control. The amount of glucose intaked and insulin administered during TPN therapy was studied by reviewing chart of patients in diabetes and pancreatic disease who had received TPN from 1994. 1 to 1995. 12 in SNUH retrospectively. Total 34 cases are divided into well-controlled level group(A:16 case) and non-controlled level group(B:18 case).
Well-controlled level group means that its blood glucose level is maintained between 100-230 ㎎/㎗ during TPN administration. Both group is subdivided into IDDM, NIDDM and pancreatic disease. We calculated Insulin and Glucose ratio (I/G) in IDDM and NIDDM of well-controlled level group. The I/G values of IDDM group and NIDDM are 0.20±0.033 and 0.077±0.01 respectively.
This result shows that IDDM´s insulin requirement is larger than NIDDM´s as expectedly(P<0.05). And when stress factor(e.g. surgery, infection) is considered, it was found that stress factor affects blood glucose control.
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KEYWORD
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